2005-2006 Grant

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Mitchell, MD, Ph.D.</B></div> <div> Duke University Medical Center</div> <div> Durham, North Carolina</div> <bR> <div> <TABLE BORDER="2" CELLPADDING="2" CELLSPACING="0" WIDTH="558" BORDERCOLORLIGHT="#000099" BORDERCOLORDARK="#0000CC" FRAME="BOX" RULES="ALL" HSPACE="0" VSPACE="0" BGCOLOR=#FF6600 > <tR> <tD VALIGN=TOP HEIGHT= 442 WIDTH="548"><div> <I><B>Identification and Immunologic Targeting of CMV Antigens </B></I><I><B>Expressed in Malignant Gliomas</B></I></div> <div> <B>Ken Grey & Dr. Duane Mitchell</B><IMG SRC="07af4770.jpg" border=0 width="500" height="375" ALIGN="BOTTOM" HSPACE="0" VSPACE="0"></div> </tD> </tR> </TABLE></div> <div> The prognosis for patients diagnosed with malignant gliomas remains very poor and the non-specific nature of standard treatment often results in damage to surrounding normal brain.  Immunotherapy directed against tumor-specific antigens holds the potential to target malignant cells more precisely, but it is severely limited because we do not have a strong understanding of the tumor rejection antigens present in human cancers.  The recent finding that human cytomegalovirus (HCMV) propagates in a large number of malignant gliomas, without infecting surrounding normal brain cells, promises to direct brain tumor immunotherapy against immunogenic viral targets.</div> <bR> <div> Recent clinical trials highlight the benefit of adoptive immunotherapy, in setting of chemotherapy-induced lymphopenia, as a powerful way to guide the recovering immune system toward anti-tumor recognition.  We propose to investigate CMV antigen expression in malignant glioma specimens, and evaluate adoptive immunotherapy following treatment-induced lymphopenia using murine model of CMV-associated astrocytomas.</div> </td> </tr></table></body>